Professor Kevin Kin Man TSIA

Biography

Kevin Tsia received his Ph.D. degree at the Electrical Engineering Department at University of California Los Angeles (UCLA) in 2009. He is currently a Professor in the Department of Electrical and Computer Engineering and the Program Director of the Biomedical Engineering Program at the University of Hong Kong. His research interest covers a broad range of subject matters including ultra-fast optical imaging for imaging flow cytometry and cell-based assay high-speed in-vivo brain imaging computational approaches for single-cell analysis. He is currently the HK Research Grants Council (RGC) Research Fellow (2020). He received Early Career Award 2012-2013 by RGC in Hong Kong. He also received the Outstanding Young Research Award 2015 at HKU as well as 14th Chinese Science and Technology Award for Young Scientists in 2016. His recent research on ultrafast optofluidic imaging technologies dubbed “ATOM” and “FACED” have also been covered by media and scientific magazines. He is author or coauthor of over 200 journal publications conference papers and book chapters. He holds 4 granted and 4 pending US patents on ultrafast optical imaging technologies. He is a co-founder of start-up company commercializing the high speed microscopy technology for cancer screening and treatment monitoring applications.

Related Links

• • Research Group Facebook Page

Selected Publications

• Qinrong Zhang, Justin S. J. Wong, Christoph Miehl, Krishnashish Bose, Xiaoyu Lu,  François St-Pierre, Su Guo, Brent Doiron, Kevin K. Tsia & Na Ji FACED 2.0 enables large-scale voltage and calcium imaging in vivo. Nature Methods (2025). https://doi.org/10.1038/s41592-025-02925-7
• Guanghan Meng, Jian Zhong, Qinrong Zhang, Justin S. J. Wong, Jianglai Wu, Kevin K. Tsia* and Na Ji*, “Ultrafast two-photon fluorescence imaging of cerebral blood circulation in the mouse brain in vivo”. PNAS. 119 (23) e2117346119 (2022)
• Q. T. K. Lai, G. G. K. Yip, J. Wu, J. S. J. Wong, M. C. K. Lo, K. C. M. Lee, Tony T. H. D. Le, Hayden K. H. So, Na Ji & Kevin K. Tsia, “High-speed laser-scanning biological microscopy using FACED”. Nature Protocols. 16, 4227 (2021).
• J. Wu, Y. Liang, S. Chen, C. Hsu, M. Chavarha, S. W. Evans, D. Shi, M. Z. Lin, Kevin K. Tsia* & Na Ji*, “Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo”. Nature Methods.17, 287 (2020)
• Y-X Ren, J. Wu, Q. T. K. Lai, H. Lai, D. M. D. Siu, Wutian Wu, K. K. Y. Wong, Kevin K. Tsia, “Parallelized volumetric fluorescence microscopy with reconfigurable coded incoherent light-sheet array”. Light: Science & Applications. 8,9 (2020).
• J.Wu, Y. Xu, J. Xu, X. Wei, A. CS Chan, A. HL Tang, A. KS Lau, B. MF Chung, H. C. Shum, E. Y Lam, K. KY Wong and Kevin K Tsia, “Ultrafast Laser-Scanning Time-Stretch Imaging at Visible Wavelengths”. Light: Science & Applications. 6, e16196 (2017) **highlighted in Nature Photonics’s (April 2017).

• Rashmi S. Murthy, Shobana V. Stassen, Dickson M. D. Siu, Michelle C. K. Lo, Gwinky G. K. Yip, Kevin K. Tsia, “Generalizable Morphological Profiling of Cells by Interpretable Unsupervised Learning”, 16, 11465. Nature Communications. (2025)
• M. C.K. Lo, D. M. D. Siu, K. C. M. Lee, J. S. J. Wong, M. C.F. Yeung, M. K.Y. Hsin, J. C.M. Ho, Kevin K. Tsia, “Information-Distilled Generative Label-Free Morphological Profiling Encodes Cellular Heterogeneity”. Advanced Science. 2024, 11 (2024)
• Stassen, S.V., Kobashi, M., Lam, E.Y. Yuanhua Huang, Joshua W. K. Ho & Kevin K. Tsia  StaVia: spatially and temporally aware cartography with higher-order random walks for cell atlases. Genome Biology 25. 224 (2024).
• Stassen, S.V., Yip, G.G.K., Wong, K.K.Y. Joshua W. K. Ho & Kevin K. Tsia, “Generalized and scalable trajectory inference in single-cell omics data with VIA. Nature Communications 12. 5528 (2021).
• Shobana V. Stassen, Dickson M. D. Siu, Kelvin C. M. Lee, Joshua W. K. Ho, Hayden K. H. So, Kevin K. Tsia. “PARC: ultrafast and accurate clustering of phenotypic data of millions of single cells”. btaa042, Bioinformatics (2020)

• Tianben Ding, Kelvin C. M. Lee, Kevin K. Tsia, T. Nicolai Siegel, Dino Di Carlo & Keisuke Goda  Image-activated cell sorting. Nature Review Bioengineering 3. 890–907 (2025).
• Thiel Lee,  Evelyn H. Y. Cheung, Kelvin C. M. Lee,  Dickson M. D. Siu, Michelle C. K. Lo, Edmund Y. Lam, Ruchi Goswami, Salvatore Girardo, Kyoohyun Kim, Felix Reichel, Marketa Kubankova, Martin Kräter, Jochen Guck  and  Kevin K. Tsia. High-throughput multimodal optofluidic biophysical imaging cytometry. Lab on a Chip. 25, 5329-5341 (2025)
• Kelvin C. M. Lee, Bob M. F. Chung, Dickson M. D. Siu, Sam C. K. Ho, Daniel K. H. Ng, Kevin K. Tsia, “Dispersion-free inertial focusing (DIF) for high-yield polydisperse micro-particles filtration and analysis”. Lab on a Chip, 24, 4182-4197 (2024)
• D.M.D Siu, KCM Lee, BMF Chung, JSJ Wong, G Zheng, KK Tsia, “Optofluidic imaging meets deep learning: from merging to emerging”. Lab on a Chip. 23 (5), 1011-1033 (2023). (Front cover in Feb 2023).
• D.M D Siu, K. C. M. Lee, M. Lo, S. V Stassen, Maolin Wang, I. Z Q Zhang, H. So, G.C F Chan, K. Cheah, Kenneth K. Y. Wong, M. Hsin, James C M Ho, Kevin K. Tsia, “Deep-learning-assisted biophysical imaging cytometry at massive throughput delineates cell population heterogeneity”. Lab on a Chip. 20, 20, 3696, 2020. (Front cover in July 2019).