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X-WR-CALNAME:Department of Electrical and Computer Engineering (HKUECE) 電機與計算機工程系
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TZID:Asia/Hong_Kong
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Hong_Kong:20260512T160000
DTEND;TZID=Asia/Hong_Kong:20260512T170000
DTSTAMP:20260512T013209
CREATED:20260511T041652Z
LAST-MODIFIED:20260511T041652Z
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SUMMARY:RPG Seminar – HOPE for Quantitative Photoacoustic Microscopy of Lipids: From Acquisition to Analysis
DESCRIPTION:Zoom Link \nhttps://hku.zoom.us/j/7489542129?pwd=EgQ5WhPS1YJcx9cbWlXa2HMbqlxJxC.1&omn=96943285907 \nAbstract\nPhotoacoustic microscopy (PAM) in the 1.7-μm absorption window has emerged as a promising modality for label-free lipid imaging due to the strong overtone absorption of C—H bonds at this wavelength. However\, quantitative lipid imaging is constrained by the performance of existing nanosecond laser sources and depth-dependent resolution degradation caused by optical scattering. In this seminar\, we present a full-stack optical-resolution PAM platform for the quantitative imaging and analysis of lipids in biological tissues. The key constituent of this platform is a novel 1725-nm hybrid optical parametric oscillator emitter (HOPE) source tailored for PAM applications. The laser source provides superior spectral energy density\, narrow bandwidth\, and high optical signal-to-noise ratio\, allowing for high-sensitivity mapping of lipids in tissues. Using this system\, we demonstrate clinically relevant differentiation of hepatic steatosis levels in ex vivo human liver specimen\, with demonstrated potential as a diagnostic tool for metabolic dysfunction-associated steatotic liver disease (MASLD). We further develop a physics-informed deconvolution framework incorporating to address scattering-induced resolution degradation in three-dimensional PAM images. The framework achieves substantial resolution recovery of up to approximately twofolds in out-of-focus regimes and is additionally applied to the volumetric visualisation of laser-induced thermal ablation lesions in human liver tissue. Together\, these developments establish a comprehensive 1.7-μm PAM framework for high-sensitivity lipid imaging and advanced volumetric tissue characterisation. \nSpeaker\nMs Najia SHARMIN\nDepartment of Electrical and Computer Engineering\nThe University of Hong Kong \nBiography of the Speaker\nMs. Najia Sharmin is a PhD candidate in the Photonic Systems Research Lab at The University of Hong Kong under the Hong Kong PhD Fellowship Scheme and the HKU Presidential PhD Scholar Programme. Her research focuses on advancing photoacoustic microscopy for biomedical applications\, combining laser system design\, optical modeling\, and image processing to improve diagnostic and translational capabilities. Her PhD work is particularly centered on non-invasive\, label-free detection of lipid distributions in human liver tissues in the 1.7-µm optical window. \nOrganiser\nProf Kenneth K.Y. Wong \nDepartment of Electrical and Computer Engineering\, The University of Hong Kong \nAll are welcome.
URL:https://ece.hku.hk/events/20260512/
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://ece.hku.hk/wp-content/uploads/2024/11/rpg-seminar.jpg
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