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X-WR-CALDESC:Events for Department of Electrical and Computer Engineering (HKUECE) 電機與計算機工程系
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TZID:Asia/Hong_Kong
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DTSTART:20240101T000000
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DTSTART;TZID=Asia/Hong_Kong:20251121T110000
DTEND;TZID=Asia/Hong_Kong:20251121T120000
DTSTAMP:20260510T192754
CREATED:20251113T061708Z
LAST-MODIFIED:20251113T061708Z
UID:113884-1763722800-1763726400@ece.hku.hk
SUMMARY:Seminar on Probing Arousal Modulation of Brain Networks Using Multimodal Functional MRI in Awake Rodents and Non-human Primates
DESCRIPTION:Abstract\nArousal fluctuation is known to contribute to fMRI based functional dynamics\, but its detailed mechanism is largely unclear. Combining invasive neural recording (electrophysiological recording and fiber photometry) and manipulation (optogenetics and chemogenetics) techniques with awake\, unanesthetized animal fMRI provides unique opportunities to unravel the arousal contribution. Highly optimized unanesthetized mouse and marmoset fMRI setups allowed a wide range of arousal states from high alertness to NREM and REM sleep\, which was identified through simultaneous electrophysiological recording. Dynamic functional connectivity analysis revealed an inverted U-shape modulation of global functional connectivity strength and functional gradient from low to high arousal level. Further combined with simultaneous fiber photometry\, our multimodal fMRI revealed direct relationship between Locus Coeruleus Norepinephrine (LC-NE) system and such modulation. Direct neuronal manipulation using optogenetics/chemogenetics simultaneously with awake mouse fMRI confirmed the causal contribution of LC-NE system to inverted u-shape modulation. In conclusion\, multimodal fMRI in awake rodent and non-human primate revealed arousal modulated inverted U-shaped functional connectivity dynamics\, which can be driven by LC-NE activity. \nSpeaker\nDr. Zhifeng LIANG\nSenior Investigator\,\nDirector of the Brain Imaging Center\,\nInstitute of Neuroscience\,\nChinese Academy of Sciences\, Shanghai \nSpeaker’s Biography\nZhifeng LIANG obtained his Bachelor of Science in Life Sciences from Fudan University and PhD in Neuroscience from the University of Massachusetts Medical School. He conducted his postdoc training at the Department of Biomedical Engineering\, Pennsylvania State University\, before joining the Institute of Neuroscience (ION)\, Chinese Academy of Sciences as an Investigator and director of 9.4T animal MRI facility. He is now Senior Investigator and Director of the Brain Imaging Center at the Institute of Neuroscience\, with a research focus on multimodal fMRI techniques and applications in neuroscience. \nOrganiser\nDr. Alex Tze Lun LEONG\nDepartment of Electrical and Electronic Engineering\,\nThe University of Hong Kong \nAcknowledgement\nTam Wing Fan Innovation Wing Two\n\nAll are welcome!
URL:https://ece.hku.hk/events/20251121-1/
LOCATION:Tam Wing Fan Innovation Wing Two\, G/F\, Run Run Shaw Building\, The University of Hong Kong
CATEGORIES:Highlights,Seminar
ATTACH;FMTTYPE=image/jpeg:https://ece.hku.hk/wp-content/uploads/2025/11/1280-2.jpg
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