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PRODID:-//Department of Electrical and Computer Engineering (HKUECE) 電機與計算機工程系 - ECPv6.16.0//NONSGML v1.0//EN
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X-ORIGINAL-URL:https://ece.hku.hk
X-WR-CALDESC:Events for Department of Electrical and Computer Engineering (HKUECE) 電機與計算機工程系
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TZID:Asia/Hong_Kong
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TZOFFSETFROM:+0800
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TZNAME:HKT
DTSTART:20230101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Hong_Kong:20240813T143000
DTEND;TZID=Asia/Hong_Kong:20240813T153000
DTSTAMP:20260512T144155
CREATED:20240712T030813Z
LAST-MODIFIED:20250114T042722Z
UID:18871-1723559400-1723563000@ece.hku.hk
SUMMARY:Mechano-nanooncology
DESCRIPTION:Abstract\nNanomedicines are an important means of treating solid tumors\, but in clinical applications\, they can only reduce side effects and cannot significantly improve efficacy. The main reason is that the rapid clearance of the reticuloendothelial system (RES) and the abnormal mechanical microenvironment of solid tumors limit the delivery efficiency of nanomedicines.The RES blockade strategy can temporarily and reversibly delay liver clearance\, improve tumor enrichment and antitumor effects of nanomedicines\, and have good biological safety. However\, the large number of nanoparticles in the circulatory system still imposes an additional burden on RES\, making it particularly important to improve the efficiency of the RES blockade strategy. We systematically explored how to use the mechanical properties of nanogel to overcome the clearing effect of RES\, and proposed the treatment strategy of antitumor effect of nanomedicines with mechanical modulation for the first time. Crucially\, RES blockade strategy based on the mechanical properties of nanogel boosts antitumor efficacy of marketed nanomedicines\, such as Doxil® And Abraxane®. Therefore\, mechano-based RES blockade has broad universality and huge clinical application potential. We propose using hyperbaric oxygen and mild photothermal therapy to improve the abnormal mechanical microenvironment of solid tumors and enhance the antitumor effect of nanomedicines. For the first time\, we discovered that hyperbaric oxygen can overcome tumor hypoxia and inhibit tumor associated fibroblasts\, regulate the abnormal mechanical microenvironment of solid tumors\, as well as the structure and function of tumor blood vessels\, thereby selectively enhancing the commercialized nanomedicines\, e.g.\, Doxil® and Abraxane® and nanoscale biological macromolecules\, such as PD-1 antibodies. In addition\, we have confirmed that the mild photothermal effect of nanomedicines efficiently depletes tumor associated fibroblasts and extracellular matrix\, reduces solid stress and stiffness of tumors\, normalizes tumor vascular structure and function\, promotes subsequent nanomedicine and oxygen delivery\, damages the ecological niche of tumor stem cells\, eliminates cancer stem cells\, and augments the antitumor effect of nanomedicines. Our results indicate that mechano-mediated regulation strategies have the potential to enhance the antitumor effect of nanomedicines. Two prospective trials have been performed in bedside. \nSpeaker\nProf. Zifu LI\nFull Professor\,\nHuazhong University of Science and Technology \nBiography of the Speaker\nProf. Zifu LI received the B.S. degree from Huazhong University of Science and Technology in 2008 and the Ph.D. degree from the Chinese University of Hong Kong in 2012. In 2013 and 2015\, he worked as a postdoctoral fellow at the University of Alberta. He then joined Georgia Institute of Technology as a research scientist. Since 2016\, he has been a full professor at Huazhong University of Science and Technology. Professor Zifu Li’s lab is based on the National Engineering Research Center for Nanomedicine at Huazhong University of Science and Technology. His research lies at the interface of biomaterials\, drug delivery\, and cellular and molecular bioengineering to fundamentally understand and therapeutically target biological molecules\, cancer cells\, immune cells\, and cancer stem cells. He applies his research findings and the technologies developed to a range of human health applications\, particularly on cancer diagnosis and treatment. Current research projects include mechano-nanooncology\, smart nanomedicine and hyperbaric oxygen-enabled cancer therapy. \nOrganizer\nProf. Zhiqin CHU \nAll are welcome! We look forward to seeing you!
URL:https://ece.hku.hk/events/20240813-1/
LOCATION:Room CB-603\, 6/F\, Chow Yei Ching Building\, The University of Hong Kong
CATEGORIES:Seminar
ATTACH;FMTTYPE=image/jpeg:https://ece.hku.hk/wp-content/uploads/2024/07/1280-1.jpg
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